The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Depression, obesity and their comorbidity during pregnancy: effects on the offspring's mental and physical health
N Cattane, K Räikkönen, R Anniverno… - Molecular …, 2021 - nature.com
Depression and obesity represent two of the most common complications during pregnancy
and are associated with severe health risks for both the mother and the child. Although …
and are associated with severe health risks for both the mother and the child. Although …
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function
The co-chaperone FKBP5 is a stress-responsive protein-regulating stress reactivity, and its
genetic variants are associated with T2D related traits and other stress-related disorders …
genetic variants are associated with T2D related traits and other stress-related disorders …
FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes
Purpose Here, we explore the involvement of FKBP51 in glucocorticoid-induced insulin
resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in …
resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in …
Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery
M Malekpour, D Shekouh, ME Safavinia… - Frontiers in …, 2023 - frontiersin.org
Stress-induced mental health disorders are affecting many people around the world.
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …
However, effective drug therapy for curing psychiatric diseases does not occur sufficiently …
Downregulation of FKBP5 promotes atrial arrhythmogenesis
Background: Atrial fibrillation (AF), the most common arrhythmia, is associated with the
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
downregulation of FKBP5 (encoding FKBP5 [FK506 binding protein 5]). However, the …
Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease
LC Dabin, F Guntoro, T Campbell, T Bélicard… - Acta …, 2020 - Springer
Prion diseases are fatal and transmissible neurodegenerative disorders caused by the
misfolding and aggregation of prion protein. Although recent studies have implicated …
misfolding and aggregation of prion protein. Although recent studies have implicated …
Role of the FKBP5 polymorphism rs1360780, age, sex, and type of surgery in weight loss after bariatric surgery: a follow-up study
Background Emerging evidence suggests that the FK506 binding protein 51
(FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation …
(FKBP5/FKBP51), encoded by the FKBP5 gene, influences weight and metabolic regulation …
Gene expression and epigenetic markers of prion diseases
Epigenetics, meaning the variety of mechanisms underpinning gene regulation and
chromatin states, plays a key role in normal development as well as in disease initiation and …
chromatin states, plays a key role in normal development as well as in disease initiation and …
[HTML][HTML] FKBP5 as a key regulator of metabolic processes in birds: Insights from chicken pectoral muscle
P Du, X Zhang, Y Zhu, Z Wang, X Si, H Zhang, Y Huang… - Poultry Science, 2025 - Elsevier
Abstract FK506-binding protein 5 (FKBP5) is a negative regulator of the glucocorticoid
response and may play an important role in regulating metabolic homeostasis in birds …
response and may play an important role in regulating metabolic homeostasis in birds …