Context-specific Polycomb mechanisms in development
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
PRC2, chromatin regulation, and human disease: insights from molecular structure and function
X Liu, X Liu - Frontiers in Oncology, 2022 - frontiersin.org
Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency
The Polycomb repressive system plays a fundamental role in controlling gene expression
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …
during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 …
Polycomb repressive complex 2 in eukaryotes—an evolutionary perspective
Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved
multi-subunit complexes that repress gene transcription by introducing trimethylation of …
multi-subunit complexes that repress gene transcription by introducing trimethylation of …
Inseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2
EH Gail, E Healy, SF Flanigan, N Jones, XH Ng… - Nature Genetics, 2024 - nature.com
Abstract Polycomb repressive complex 2 (PRC2) interacts with RNA in cells, but there is no
consensus on how RNA regulates PRC2 canonical functions, including chromatin …
consensus on how RNA regulates PRC2 canonical functions, including chromatin …
CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site
Abstract Polycomb repressive complex 2 (PRC2) plays a key role in maintaining cell identity
during differentiation. Methyltransferase activity of PRC2 on histone H3 lysine 27 is …
during differentiation. Methyltransferase activity of PRC2 on histone H3 lysine 27 is …
[HTML][HTML] Nox4 promotes endothelial differentiation through chromatin remodeling
Rationale Nox4 is a constitutively active NADPH oxidase that constantly produces low levels
of H 2 O 2. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as …
of H 2 O 2. Thereby, Nox4 contributes to cell homeostasis and long-term processes, such as …
Polycomb‐mediated gene regulation in human brain development and neurodevelopmental disorders
N Bölicke, M Albert - Developmental neurobiology, 2022 - Wiley Online Library
The neocortex is considered the seat of higher cognitive function in humans. It develops
from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This …
from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This …
Histone methylation modification and diabetic kidney disease: Potential molecular mechanisms and therapeutic approaches
P Qu, L Li, Q **, D Liu, Y Qiao… - International …, 2024 - spandidos-publications.com
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-
stage renal disease, and is characterized by persistent proteinuria and decreased …
stage renal disease, and is characterized by persistent proteinuria and decreased …
LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells
Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular
development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in …
development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in …