Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Profound and debilitating fatigue is the most common complaint reported among individuals
with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 …

Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

Quantitative traits analyzed in Genome-Wide Association Studies (GWAS) are often
nonnormally distributed. For such traits, association tests based on standard linear …

Rationale: Obstructive sleep apnea is a risk factor for mortality, but its diagnostic metric—the
apnea–hypopnea index—is a poor risk predictor. The apnea–hypopnea index does not …

Although next-generation sequencing has revolutionized the ability to associate variants
with human diseases, diagnostic rates and development of new therapies are still limited by …

Obstructive sleep apnea syndrome (OSAS) is characterized by intermittent hypoxia (IH)
during sleep due to recurrent upper airway obstruction. The derived oxidative stress (OS) …

Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Considerable recent advancements in elucidating the genetic architecture of sleep traits and
sleep disorders may provide insight into the relationship between sleep and obesity. Despite …