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Spatial proteomics: a powerful discovery tool for cell biology
Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …
Application of machine learning in spatial proteomics
Spatial proteomics is an interdisciplinary field that investigates the localization and dynamics
of proteins, and it has gained extensive attention in recent years, especially the subcellular …
of proteins, and it has gained extensive attention in recent years, especially the subcellular …
Intrathecal AAV9/AP4M1 gene therapy for hereditary spastic paraplegia 50 shows safety and efficacy in preclinical studies
Spastic paraplegia 50 (SPG50) is an ultrarare childhood-onset neurological disorder caused
by biallelic loss-of-function variants in the AP4M1 gene. SPG50 is characterized by …
by biallelic loss-of-function variants in the AP4M1 gene. SPG50 is characterized by …
Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning
Background Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-
infection, referred to as “Long-COVID”. A lack of Long-COVID biomarkers and …
infection, referred to as “Long-COVID”. A lack of Long-COVID biomarkers and …
Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging
X Liu, D Mao, Y Song, L Zhu, AN Isak, C Lu, G Deng… - Science …, 2022 - science.org
In situ spatial proteomics analysis of a single cell has not been achieved yet, mainly
because of insufficient throughput and sensitivity of current techniques. Recent progress on …
because of insufficient throughput and sensitivity of current techniques. Recent progress on …
SLC26A4-AP-2 mu2 interaction regulates SLC26A4 plasma membrane abundance in the endolymphatic sac
HJ Lee, C Fenollar-Ferrer, K Isgrig, YX Wang… - Science …, 2024 - science.org
Decreased presence or activity of human SLC26A4 at the plasma membrane is a common
cause of hearing loss. SLC26A4 (Pendrin) is necessary for normal reabsorption of …
cause of hearing loss. SLC26A4 (Pendrin) is necessary for normal reabsorption of …
Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome
The hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous
group of disorders characterized by progressive lower limb spasticity. Mutations in subunits …
group of disorders characterized by progressive lower limb spasticity. Mutations in subunits …
Recent advancements in subcellular proteomics: growing impact of organellar protein niches on the understanding of cell biology
The mammalian cell is a complex entity, with membrane-bound and membrane-less
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …
Subcellular proteomics
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …
Spatial proteomics toward subcellular resolution by coupling deep ultraviolet laser ablation with nanodroplet sample preparation
Multiplexed molecular profiling of tissue microenvironments, or spatial omics, can provide
critical insights into cellular functions and disease pathology. The coupling of laser …
critical insights into cellular functions and disease pathology. The coupling of laser …