The collective efforts of scientists over multiple decades have led to advancements in
molecular and cellular biology-based technologies including genetic engineering and …

Animal experimentation is necessary to characterize human diseases and design adequate
therapeutic interventions. In renal transplantation research, the limited number of in vitro …

MICA are distant homologs of MHC class I molecules expressed in the normal intestinal
epithelium. They are ligands of the NKG2D activating receptor expressed on most γδ T cells …

Pigs are capable of generating reassortant influenza viruses of pandemic potential, as both
the avian and mammalian influenza viruses can infect pig epithelial cells in the respiratory …

A large number of hDAF transgenic pigs to be used for xenotransplantation research were
generated by using sperm-mediated gene transfer (SMGT). The efficiency of transgenesis …

Background. The genetic modification of pigs is a powerful strategy that may ultimately
enable successful xenotransplantation of porcine organs into humans. Methods. Transgenic …

Background. Recently, there has been a resumed interest in clinical xenotransplantation
using pig organs. However, no data are available yet regarding the capacity of porcine …

Rejection of xenografts is associated with vascular‐based inflammation, thrombocytopenia
and the consumption of coagulation factors that may evolve into disseminated intravascular …

Background. It is not known whether the pig liver is capable of functioning efficiently when
transplanted into a primate, neither is there experience in transplanting a liver from a …

Human membrane cofactor protein (CD46) controls complement activation and when
expressed sufficiently as a transgene protects xenografts against complement‐mediated …