Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus
(iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles. iNPH and …

The cerebrospinal fluid (CSF) is the primary circulating fluid of the central nervous system. It
serves numerous important physiologic and maintenance functions, and its production and …

To what extent does the subarachnoid cerebrospinal fluid (CSF) compartment communicate
directly with the extravascular compartment of human brain tissue? Interconnection between …

Among the various disorders manifesting dementia, gait disturbance, and urinary
incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is …

None of the proposed mechanisms of Alzheimer's disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

The glymphatic system plays a key role for clearance of waste solutes from the rodent brain.
We recently found evidence of glymphatic circulation in the human brain when using …

The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …

We assessed the prevalence of common altered brain proteins in 296 cognitively
unimpaired subjects ranging from age 50 to 102 years. The incidence and the stage of …

There is evidence that production and turnover of CSF help to clear toxic molecules such as
amyloid-β peptide (Aβ) from the interstitial‐fluid space of the brain to the bloodstream. Two …

Idiopathic normal pressure hydrocephalus (NPH) remains both oversuspected on clinical
grounds and underconfirmed when based on immediate and sustained response to …