Chalcones as potential ligands for the treatment of Parkinson's disease
E Królicka, K Kieć-Kononowicz, D Łażewska - Pharmaceuticals, 2022 - mdpi.com
Along with the increase in life expectancy, a significant increase of people suffering from
neurodegenerative diseases (ND) has been noticed. The second most common ND, after …
neurodegenerative diseases (ND) has been noticed. The second most common ND, after …
Indanone: a promising scaffold for new drug discovery against neurodegenerative disorders
Indanone is a versatile scaffold that has a number of pharmacological properties. The
successful development and ensuing approval of indanone-derived donepezil as a drug of …
successful development and ensuing approval of indanone-derived donepezil as a drug of …
Dual A1 and A2A adenosine receptor antagonists, methoxy substituted 2-benzylidene-1-indanone, suppresses intestinal postprandial glucose and attenuates …
Abstract Background/Aim Recent research suggests that adenosine receptors (ARs)
influence many of the metabolic abnormalities associated with diabetes. A non-xanthine …
influence many of the metabolic abnormalities associated with diabetes. A non-xanthine …
[HTML][HTML] Striatal adenosine A2A receptor involvement in normal and large nest building deer mice: Perspectives on compulsivity and anxiety
D Saaiman, L Brand, G de Brouwer… - Behavioural Brain …, 2023 - Elsevier
Obsessive-compulsive disorder (OCD) is characterized by recurring obsessive thoughts and
repetitive behaviors that are often associated with anxiety and perturbations in cortico …
repetitive behaviors that are often associated with anxiety and perturbations in cortico …
Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors
MA Qhobosheane, LJ Legoabe, B Josselin… - Bioorganic & Medicinal …, 2020 - Elsevier
Protein kinases are important drug targets, especially in the area of oncology. This paper
reports the synthesis and biological evaluation of new 7-azaindole derivatives bearing …
reports the synthesis and biological evaluation of new 7-azaindole derivatives bearing …
Chalcone‐inspired rA1/A2A adenosine receptor ligands: Ring closure as an alternative to a reactive substructure
Over the past few years, great progress has been made in the development of high‐affinity
adenosine A1 and/or A2A receptor antagonists—promising agents for the potential …
adenosine A1 and/or A2A receptor antagonists—promising agents for the potential …
C3 amino-substituted chalcone derivative with selective adenosine rA1 receptor affinity in the micromolar range
To identify novel adenosine receptor (AR) ligands based on the chalcone scaffold, herein
the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15–36 …
the synthesis, characterization and in vitro and in silico evaluation of 33 chalcones (15–36 …
Exploration of chalcones and related heterocycle compounds as ligands of adenosine receptors: therapeutics development
Adenosine receptors (ARs) are ubiquitously distributed throughout the mammalian body
where they are involved in an extensive list of physiological and pathological processes that …
where they are involved in an extensive list of physiological and pathological processes that …
Synthesis and evaluation of methoxy substituted 2-benzoyl-1-benzofuran derivatives as lead compounds for the development adenosine A1 and/or A2A receptor …
A series of fourteen methoxy substituted 2-benzoyl-1-benzofuran derivatives were
synthesised and their affinities determined for adenosine A 1 and A 2A receptors via …
synthesised and their affinities determined for adenosine A 1 and A 2A receptors via …
Cationic Gold‐Catalyzed Intramolecular Cyclization of Substituted 1, 5‐Diynes to Access Indenone Derivatives
An efficient intramolecular cyclization reaction was developed to achieve indenone
derivatives. The substituted 1, 5‐diyenes were converted to the corresponding indenones …
derivatives. The substituted 1, 5‐diyenes were converted to the corresponding indenones …