Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Gut-derived metabolite, trimethylamine-N-oxide (TMAO) in cardio-metabolic diseases: detection, mechanism, and potential therapeutics

M Shanmugham, S Bellanger, CH Leo - Pharmaceuticals, 2023 - mdpi.com
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary
metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely …

Vascular actions of relaxin: nitric oxide and beyond

CH Leo, M Jelinic, HH Ng, SA Marshall… - British journal of …, 2017 - Wiley Online Library
The peptide hormone relaxin regulates the essential maternal haemodynamic adaptations
in early pregnancy through direct actions on the renal and systemic vasculature. These …

Valorization of avocado seeds with antioxidant capacity using pressurized hot water extraction

ES Ong, J Low, JCW Tan, SY Foo, CH Leo - Scientific Reports, 2022 - nature.com
The pulp of avocado (Persea Americana) is widely consumed as the primary food source,
while the seed is often discarded as food waste. Increased consumption of avocado would …

The actions of relaxin on the human cardiovascular system

M Sarwar, XJ Du, TB Dschietzig… - British Journal of …, 2017 - Wiley Online Library
The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …

Pressurized hot water extraction of okra seeds reveals antioxidant, antidiabetic and vasoprotective activities

ES Ong, CLY Oh, JCW Tan, SY Foo, CH Leo - Plants, 2021 - mdpi.com
Abelmoschus esculentus L. Moench (okra) is a commonly consumed vegetable that consists
of the seeds and peel component which are rich in polyphenolic compounds. The aim of this …

Endothelium-dependent relaxation is impaired in Schlager hypertensive (BPH/2J) mice by region-specific mechanisms in conductance and resistance arteries

M Jelinic, KL Jackson, K O'Sullivan, J Singh, T Giddy… - Life Sciences, 2023 - Elsevier
Aims Endothelial dysfunction and arterial stiffness are hallmarks of hypertension, and major
risk factors for cardiovascular disease. BPH/2J (Schlager) mice are a genetic model of …

Evidence of vascular involvement in myopia: a review

A Benavente-Perez - Frontiers in Medicine, 2023 - frontiersin.org
The benign public perception of myopia (nearsightedness) as a visual inconvenience masks
the severity of its sight-threatening consequences. Myopia is a significant risk factor for …

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

HH Ng, CH Leo, D Prakoso, C Qin, RH Ritchie… - Scientific Reports, 2017 - nature.com
Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis
in cardiomyocytes under acute hyperglycaemia. Less is known about the effects of serelaxin …

Antioxidant and Cytoprotective Effect of Quinoa (Chenopodium quinoa Willd.) with Pressurized Hot Water Extraction (PHWE)

ES Ong, CJN Pek, JCW Tan, CH Leo - Antioxidants, 2020 - mdpi.com
Quinoa is widely noted for its nutritional value. The seed is the main edible part of the plant
and exists in at least three different colors: white, red and black. This study utilized a …