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A short guide to histone deacetylases including recent progress on class II enzymes
SY Park, JS Kim - Experimental & molecular medicine, 2020 - nature.com
The interaction between histones and DNA is important for eukaryotic gene expression. A
loose interaction caused, for example, by the neutralization of a positive charge on the …
loose interaction caused, for example, by the neutralization of a positive charge on the …
The roles of histone deacetylases and their inhibitors in cancer therapy
G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
HDAC6 as privileged target in drug discovery: A perspective
S Pulya, SA Amin, N Adhikari, S Biswas, T Jha… - Pharmacological …, 2021 - Elsevier
Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …
physiological functions. Besides histone modification, largely due to its cytoplasmic …
50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond
Abstract In 1964, Vincent Allfrey and colleagues reported the identification of histone
acetylation and with deep insight proposed a regulatory role for this protein modification in …
acetylation and with deep insight proposed a regulatory role for this protein modification in …
From 1957 to nowadays: a brief history of epigenetics
P Peixoto, PF Cartron, AA Serandour… - International journal of …, 2020 - mdpi.com
Due to the spectacular number of studies focusing on epigenetics in the last few decades,
and particularly for the last few years, the availability of a chronology of epigenetics appears …
and particularly for the last few years, the availability of a chronology of epigenetics appears …
Epigenetic modifications: basic mechanisms and role in cardiovascular disease
DE Handy, R Castro, J Loscalzo - Circulation, 2011 - ahajournals.org
The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …
and the environment that are involved in development and differentiation in higher …
Erasers of histone acetylation: the histone deacetylase enzymes
E Seto, M Yoshida - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there …
groups from the lysine residues of both histone and nonhistone proteins. In humans, there …
[HTML][HTML] Targeting histone deacetylases with natural and synthetic agents: an emerging anticancer strategy
AK Singh, A Bishayee, AK Pandey - Nutrients, 2018 - mdpi.com
Cancer initiation and progression are the result of genetic and/or epigenetic alterations.
Acetylation-mediated histone/non-histone protein modification plays an important role in the …
Acetylation-mediated histone/non-histone protein modification plays an important role in the …
Histone deacetylases (HDACs): characterization of the classical HDAC family
Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …
influenced by the post-translational modification of histones, the building blocks of …
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
PC Mahon, K Hirota, GL Semenza - Genes & development, 2001 - genesdev.cshlp.org
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of oxygen homeostasis that controls
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …
angiogenesis, erythropoiesis, and glycolysis via transcriptional activation of target genes …