RISPR-Cas9 has exhibited enormous potential in gene therapy. It can perform genome
editing with single-nucleotide precision in various types of cell and tissue, providing a …

Lipid nanoparticles (LNPs) are currently the most promising clinical nucleic acids drug
delivery vehicles. LNPs prevent the degradation of cargo nucleic acids during blood …

Exosomal miRNAs play a critical role in cancer biology and could be potential biomarkers
for cancer diagnosis. However, due to the low abundance of miRNAs in the exosomes …

CRISPR/Cas9 systems have great potential to achieve sophisticated gene therapy and cell
engineering by editing multiple genomic loci. However, to achieve efficient multiplex gene …

Effective repolarization of macrophages has emerged as a promising approach for
anticancer therapy. However, there are very few studies on the effect of reprogramming …

The emergence and development of antibiotic resistance in bacteria is a serious threat to
global public health. Antibiotic resistance genes (ARGs) are often located on mobile genetic …

In recent decades, clustered regularly interspaced short palindromic repeat/CRISPR-
associated protein (CRISPR/Cas) has become one of the most promising genome-editing …

Triple-negative breast cancer (TNBC) is the most violent class of tumor and accounts for 20–
24% of total breast carcinoma, in which frequently rare mutation occurs in high frequency …

The efficient cytosolic delivery of the CRISPR-Cas9 machinery remains a challenge for
genome editing. Herein, we performed ligand screening and identified a guanidinobenzol …

Genetic editing technologies have emerged as a potential therapeutic tool in various
biomedical fields owing to their applications against cancer, neurological diseases …