Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …

Hidradenitis suppurativa, also known as acne inversa, is a chronic, often debilitating disease
primarily affecting the axillae, perineum, and inframammary regions. Prevalence rates of up …

Intermediate filaments are assembled from a diverse group of evolutionary conserved
proteins and are specified in a tissue-dependent, cell type-dependent, and context …

The rare skin disorder pachyonychia congenita (PC) is an autosomal dominant syndrome
that includes a disabling plantar keratoderma for which no satisfactory treatment is currently …

Mutations in the type I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause
pachyonychia congenita (PC), a disorder typified by dystrophic nails, painful hyperkeratotic …

Keratins, the major structural protein of all epithelia are a diverse group of cytoskeletal
scaffolding proteins that form intermediate filament networks, providing structural support to …

Long-term research on various types of RNAs has led to further understanding of diverse
mechanisms, which eventually resulted in the rapid development of RNA-based …

Non-viral gene therapy for hereditary skin diseases is an attractive prospect. However,
research efforts dedicated to this area are rare. Taking advantage of the branched structural …

In humans, inherited variation in the number, size, and shape of teeth within the dentitions
are relatively common, while rarer defects of hard tissue formation, including amelogenesis …

BACKGROUND: Pachyonychia congenita (PC) is a group of autosomal dominant
keratinizing disorders caused by a mutation in one of 4 keratin genes. Previous classification …