Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity: Supplementary issue: Brain plasticity and repair

TF Beckhauser, J Francis-Oliveira… - Journal of …, 2016 - journals.sagepub.com
In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Rostral ventrolateral medulla and hypertension

PG Guyenet, RL Stornetta, BB Holloway… - …, 2018 - Am Heart Assoc
560 Hypertension September 2018 of interest in the potential contribution of sympatho-
respiratory coupling to SNA elevation in neurogenic hypertension. As summarized below …

[HTML][HTML] CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla

S Zhang, X Wang, G Chen, L Tong, T Dai, L Wang… - Redox Biology, 2023 - Elsevier
Rostral ventrolateral medulla (RVLM) is thought to serve as a major vasomotor center that
participates in controlling the progression of stress-induced hypertension (SIH). Circular …

Androgens modulate chronic intermittent hypoxia effects on brain and behavior

B Snyder, P Duong, J Trieu, RL Cunningham - Hormones and behavior, 2018 - Elsevier
Sleep apnea is associated with testosterone dysregulation as well as increased risk of
develo** neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's …

Sympathoexcitation following intermittent hypoxia in rat is mediated by circulating angiotensin II acting at the carotid body and subfornical organ

SJ Kim, AY Fong, PM Pilowsky… - The Journal of …, 2018 - Wiley Online Library
Key points In anaesthetized rats, acute intermittent hypoxia increases sympathetic nerve
activity, sympathetic peripheral chemoreflex sensitivity and central sympathetic–respiratory …

Elevated oxidative stress and inflammation in hypothalamic paraventricular nucleus are associated with sympathetic excitation and hypertension in rats exposed to …

T Li, Y Chen, C Gua, B Wu - Frontiers in physiology, 2018 - frontiersin.org
Obstructive sleep apnea (OSA), characterized by recurrent collapse of the upper airway
during sleep leading to chronic intermittent hypoxia (CIH), is an independent risk factor for …

Role of carotid body in intermittent hypoxia-related hypertension

R Iturriaga, MP Oyarce, ACR Dias - Current hypertension reports, 2017 - Springer
Obstructive sleep apnea (OSA), a common breathing disorder, is recognized as an
independent risk factor for systemic hypertension. Among the alterations induced by OSA …

Chronic intermittent hypoxia-mediated renal sympathetic nerve activation in hypertension and cardiovascular disease

K Takahashi, S Ueda, T Kobayashi, A Nishiyama… - Scientific reports, 2018 - nature.com
In sleep apnea syndrome (SAS), chronic intermittent hypoxia (CIH) is believed to activate the
sympathetic nerve system, and is thus involved in cardiovascular diseases (CVD). However …

Chronic intermittent hypoxia enhances glycinergic inhibition in nucleus tractus solitarius

S Jia, N Rybalchenko, K Kunwar… - Journal of …, 2022 - journals.physiology.org
Chronic intermittent hypoxia (CIH), an animal model of sleep apnea, has been shown to
alter the activity of second-order chemoreceptor neurons in the caudal nucleus of the solitary …