Fluid overload and mortality in adult critical care patients—a systematic review and meta-analysis of observational studies
Objective: Fluid administration in combination with the increase in vasopermeability induced
by critical illness often results in significant fluid overload in critically ill patients. Recent …
by critical illness often results in significant fluid overload in critically ill patients. Recent …
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …
Restriction of intravenous fluid in ICU patients with septic shock
Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …
septic shock, but higher fluid volumes have been associated with harm in patients who are …
Fluid management, intra-abdominal hypertension and the abdominal compartment syndrome: a narrative review
R Jacobs, RD Wise, I Myatchin, D Vanhonacker… - Life, 2022 - mdpi.com
Background: General pathophysiological mechanisms regarding associations between fluid
administration and intra-abdominal hypertension (IAH) are evident, but specific effects of …
administration and intra-abdominal hypertension (IAH) are evident, but specific effects of …
Everything you need to know about deresuscitation
While fluid administration is one of the most common therapeutic interventions in critical
care, it carries high potential for harm as overzealous fluid resuscitation may lead to …
care, it carries high potential for harm as overzealous fluid resuscitation may lead to …
Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial
Purpose We compared a restrictive fluid management strategy to usual care among critically
ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation. Methods …
ill patients with acute kidney injury (AKI) who had received initial fluid resuscitation. Methods …
Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
Purpose To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid
therapy in adult intensive care unit (ICU) patients with septic shock included in the European …
therapy in adult intensive care unit (ICU) patients with septic shock included in the European …
[HTML][HTML] Active fluid de-resuscitation in critically ill patients with septic shock: A systematic review and meta-analysis
AS Messmer, T Dill, M Müller… - European journal of …, 2023 - Elsevier
Purpose To evaluate the impact of active fluid de-resuscitation on mortality in critically ill
patients with septic shock. Methods A systematic search was performed on PubMed …
patients with septic shock. Methods A systematic search was performed on PubMed …
Fluid overload phenotypes in critical illness—a machine learning approach
AS Messmer, M Moser, P Zuercher… - Journal of clinical …, 2022 - mdpi.com
Background: The detrimental impact of fluid overload (FO) on intensive care unit (ICU)
morbidity and mortality is well known. However, research to identify subgroups of patients …
morbidity and mortality is well known. However, research to identify subgroups of patients …
Restrictive fluids versus standard care in adults with sepsis in the emergency department (REFACED): A multicenter, randomized feasibility trial
MK Jessen, LW Andersen… - Academic …, 2022 - Wiley Online Library
Background Fluid treatment in sepsis is a challenge and clinical equipoise exists regarding
intravenous (IV) volumes. We aimed to determine whether a 24‐h protocol restricting IV fluid …
intravenous (IV) volumes. We aimed to determine whether a 24‐h protocol restricting IV fluid …