Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

Bacteria represent one of the most evolutionarily successful groups of organisms to inhabit
Earth. Their world is awash with mechanical cues, probably the most ancient form of which …

Fibronectin (FN) is a major extracellular matrix (ECM) protein involved in a wide range of
physiological processes, including cell migration. These FN-mediated cell migration events …

Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic
LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge …

Highlights•Innate mesenchymal-stroma maintains a tumor-suppressive homeostatic
equilibrium.•Fibroblastic-ECM interplay is referred to as stromal dynamic reciprocity.• …

All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …

Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and
respond to mechanical stimuli, translating them into biochemical signals in a process known …

The role of the extracellular matrix (ECM) and mechanotransduction as an important
signaling factor in the human uterus is just beginning to be appreciated. The ECM is not only …

The nuclear pore complex (NPC) is a large protein assembly that perforates the nuclear
envelope and provides a sole gateway for traffic between the cytoplasm and the nucleus …