B and T lymphocytes are the mediators of immunity, but their function is under the control of
dendritic cells. Dendritic cells in the periphery capture and process antigens, express …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

The molecular details of antigen processing and presentation by MHC class I and class II
molecules have been studied extensively for almost three decades. Although the basic …

Antigenic peptide-loaded MHC class II molecules (peptide–MHC class II) are constitutively
expressed on the surface of professional antigen-presenting cells (APCs), including …

Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture
of how MHC class I and MHC class II molecules really work. This is a story of the proteases …

Dendritic cells (DCs) are professional antigen presenting cells with the unique capacity to
induce primary and secondary immune responses in vivo. Here, we show that DCs secrete …

It is easy to be fascinated by dendritic cells (DCs), not only because of their pivotal role in the
immune response, but also because of the elegance with which they perform their tasks …

Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides,
and load these peptides onto major histocompatibility complex (MHC) class I and II …

Dendritic cells (DCs) have the capacity to initiate immune responses, but it has been
postulated that they may also be involved in inducing peripheral tolerance. To examine the …

A properly functioning adaptive immune system signifies the best features of life. It is diverse
beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad …