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Epigenetics-targeted drugs: Current paradigms and future challenges
W Dai, X Qiao, Y Fang, R Guo, P Bai, S Liu… - … and Targeted Therapy, 2024 - nature.com
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …
[HTML][HTML] Exploring the role of ribosomal RNA modifications in cancer
Highlights•Ribosomal RNA modifications are critical for ribosome function and their
dysregulation is associated with pathogenesis.•2'-O-me methylation patterns are highly …
dysregulation is associated with pathogenesis.•2'-O-me methylation patterns are highly …
[HTML][HTML] Clinical Perspectives in Epitranscriptomics
E Santos-Pujol, C Quero-Dotor, M Esteller - Current Opinion in Genetics & …, 2024 - Elsevier
Highlights•Epitranscriptomics refers to all chemical marks on RNA regulating gene
expression.•The epitranscriptome is altered in several prevalent diseases.•Disease-specific …
expression.•The epitranscriptome is altered in several prevalent diseases.•Disease-specific …
Functional Impacts of Epitranscriptomic m6A Modification on HIV-1 Infection
Epitranscriptomic RNA modifications play a crucial role in the posttranscriptional regulation
of gene expression. N 6-methyladenosine (m6A) is the most prevalent internal modification …
of gene expression. N 6-methyladenosine (m6A) is the most prevalent internal modification …