Genome editing has been a transformative force in the life sciences and human medicine,
offering unprecedented opportunities to dissect complex biological processes and treat the …

The CRISPR/Cas system, identified as a type of bacterial adaptive immune system, have
attracted significant attention due to its remarkable ability to precisely detect and eliminate …

Gene editing has the potential to solve fundamental challenges in agriculture,
biotechnology, and human health. CRISPR-based gene editors derived from microbes …

Target proteins that lack accessible binding pockets and conformational stability have posed
increasing challenges for drug development. Induced proximity strategies, such as …

Cas12a is a widely used programmable nuclease for genome editing across a variety of
organisms, but its application is limited by its PAM recognition restriction. To alleviate these …

The application of rapidly growing CRISPR toolboxes and methods has great potential to
transform biomedical research. Here, we provide a snapshot of up-to-date CRISPR …

The Cas9 endonuclease of the CRISPR/Cas type IIA system from Streptococcus pyogenes
is the heart of genome editing technology that can be used to treat human genetic and viral …

Coherent dynamics of interacting quantum particles plays a central role in the study of
strongly correlated quantum matter and the pursuit of quantum information processors. Here …

AlphaFold and similar groundbreaking, AI‐based tools, have revolutionized the field of
structural bioinformatics, with their remarkable accuracy in ab‐initio protein structure …

The development of gene editing tools has been a significant area of research in the life
sciences for nearly 30 years. These tools have been widely utilized in disease detection and …