The transcription factor NF-κB plays a major role in coordinating innate and adaptative
immunity, cellular proliferation, apoptosis and development. Since the discovery in 1991 that …

Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor
that has a broad impact on endothelial cell function. The lung tissue is very rich in this …

Abstract B-cell lymphoma 2 (BCL2) proteins are important cell death regulators, whose main
function is to control the release of cytochrome c from mitochondria in the intrinsic apoptotic …

Tumor necrosis factor (TNF) superfamily is a group of cytokines with important functions in
immunity, inflammation, differentiation, control of cell proliferation, and apoptosis. TNFα is …

Changes in the intracellular redox environment of cells have been reported to be critical for
the activation of apoptotic enzymes and the progression of programmed cell death …

The Bcl-2 family members rigorously regulate cell endogenous apoptosis, and targeting anti-
apoptotic members is a hot topic in design of anti-cancer drugs. At present, FDA and EMA …

Abstract Purpose: Azanucleoside DNA methyltransferase (DNMT) inhibitors are currently
approved by the US Food and Drug Administration for treatment of myelodysplastic …

The infiltration and persistence of hematopoietic immune cells within the rheumatoid arthritis
(RA) joint results in elevated levels of pro-inflammatory cytokines, increased reactive oxygen …

FOXL2 is a gene encoding a forkhead transcription factor, whose mutations are responsible
for the blepharophimosis-ptosis-epicanthus inversus syndrome that often involves …

Background For decades, the basic treatment strategies of necrotizing soft tissue infections
(NSTI) have remained unchanged, primarily relying on aggressive surgical removal of …