Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …

Many extracellular matrices (ECMs) have a filamentous architecture, which influences cell
growth and phenotype and imparts tissues with specific properties. Man-made fibrillar …

Pancreatic ductal adenocarcinoma (PDAC) therapeutic resistance is largely attributed to a
unique tumor microenvironment embedded with an abundance of cancer-associated …

The tumor microenvironment (TME) is a complex meshwork of extracellular matrix (ECM)
macromolecules filled with a collection of cells including cancer-associated fibroblasts …

Highlights•Tumors exaggerate and exploit natural immunosuppressive and tolerogenic
mechanisms.•This milieu favors angiogenesis and tissue remodeling but is suppressive for T …

Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury
such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars …

Cancer-associated fibrosis is a critical component of the tumor microenvironment (TME)
which significantly impacts cancer behavior. However, there is significant controversy …

The stroma in solid tumors contains a variety of cellular phenotypes and signaling pathways
associated with wound healing, leading to the concept that a tumor behaves as a wound that …

ABSTRACT The α1β1, α2β1, α10β1 and α11β1 integrins constitute a subset of the integrin
family with affinity for GFOGER-like sequences in collagens. Integrins α1β1 and α2β1 were …