The golden age of transfer hydrogenation

D Wang, D Astruc - Chemical reviews, 2015 - ACS Publications
Hydrogenation is one of the most fundamental transformations in organic synthesis, and its
industrial applications span from fine chemicals to pharmaceuticals synthesis. 1− 3 Direct …

The role of the metal-bound N–H functionality in Noyori-type molecular catalysts

PA Dub, JC Gordon - Nature Reviews Chemistry, 2018 - nature.com
Noyori-type catalysts have found numerous applications in research and industrial settings.
The central mechanistic component of such catalysts is a metal centre coordinated to a N–H …

Metal–ligand bifunctional catalysis: the “accepted” mechanism, the issue of concertedness, and the function of the ligand in catalytic cycles involving hydrogen atoms

PA Dub, JC Gordon - ACS Catalysis, 2017 - ACS Publications
For years, following the ideas of Shvo and Noyori, the core assumption of metal–ligand
bifunctional molecular catalysis has relied on the direct involvement of the chelating ligand …

The mechanism of enantioselective ketone reduction with Noyori and Noyori–Ikariya bifunctional catalysts

PA Dub, JC Gordon - Dalton Transactions, 2016 - pubs.rsc.org
The catalytic hydrogenation of prochiral ketones with second and third-row transition metal
complexes bearing chelating chiral ligands containing at least one N–H functionality has …

Broader, greener, and more efficient: Recent advances in asymmetric transfer hydrogenation

C Wang, X Wu, J **ao - Chemistry–An Asian Journal, 2008 - Wiley Online Library
Asymmetric transfer hydrogenation has become a practically useful tool in reduction
chemistry in the last decade or so. This was largely triggered by the seminal work of Noyori …

Why does alkylation of the N–H functionality within M/NH bifunctional Noyori-type catalysts lead to turnover?

PA Dub, BL Scott, JC Gordon - Journal of the American Chemical …, 2017 - ACS Publications
Molecular metal/NH bifunctional Noyori-type catalysts are remarkable in that they are among
the most efficient artificial catalysts developed to date for the hydrogenation of carbonyl …

Recent advances in metal catalysts with hybrid ligands

WH Zhang, SW Chien, TSA Hor - Coordination Chemistry Reviews, 2011 - Elsevier
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A Stable Anionic N-heterocyclic carbene and its zwitterionic complexes

V César, N Lugan, G Lavigne - Journal of the American Chemical …, 2008 - ACS Publications
Pyrimidinium betaïnes (1), readily accessible via a straightforward modular synthesis from a
formamidine and a monosubstituted malonic acid, are readily deprotonated by n BuLi (or …

Transfer Hydrogenation of Nitriles, Olefins, and N-Heterocycles Catalyzed by an N-Heterocyclic Carbene-Supported Half-Sandwich Complex of Ruthenium

VH Mai, GI Nikonov - Organometallics, 2016 - ACS Publications
In the presence of KOBut, N-heterocyclic carbene-supported half-sandwich complex [Cp
(IPr) Ru (pyr) 2][PF6](3)(IPr= 1, 3-bis (2, 6-diisopropylphenyl) imidazol-2-ylidene) catalyzes …

Chiral (η6-p-Cymene)ruthenium(II) Complexes Containing Monodentate Acylthiourea Ligands for Efficient Asymmetric Transfer Hydrogenation of Ketones

MM Sheeba, M Muthu Tamizh, LJ Farrugia… - …, 2014 - ACS Publications
The new chiral ligands (R)-/(S)-N-((1-phenylethyl) carbamothioyl) benzamide (L1/L2),(R)-
/(S)-N-((1-phenylethyl) carbamothioyl) thiophene-2-carboxamide (L3/L4), and (R)-/(S)-N-((1 …