Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

The human mitochondrial genome is extremely small compared with the nuclear genome,
and mitochondrial genetics presents unique clinical and experimental challenges. Despite …

Phylogeography is a discipline concerned with various relationships between gene
genealogies—phylogenetics—and geography. The word “phylogeography” was coined in …

Mutations in mitochondrial DNA (mtDNA) occur at high frequency in human tumors, but
whether these mutations alter tumor cell behavior has been unclear. We used cytoplasmic …

▪ Abstract The inheritance of mitochondrial and chloroplast genes differs from that of nuclear
genes in showing vegetative segregation, uniparental inheritance, intracellular selection …

This report describes a 28-year-old man with lifelong exercise intolerance. Evaluation
revealed a mitochondrial myopathy due to a novel 2-bp mitochondrial DNA deletion in the …

The hiatus between oocyte and embryonic gene transcription dictates a role for stored
maternal factors in early mammalian development. Encoded by maternal-effect genes, these …

Introduction In the last 10 years the field of mitochondrial genetics has widened, shifting the
focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) …

▪ Abstract Several unique properties of human mitochondrial DNA (mtDNA), including its
high copy number, maternal inheritance, lack of recombination, and high mutation rate, have …

Prior to activation of the embryonic genome, the initiating events of mammalian development
are under maternal control and include fertilization, the block to polyspermy and processing …