Regulation of epithelial transitional states in murine and human pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …
regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar …
Genetics and genomics of pulmonary fibrosis: charting the molecular landscape and sha** precision medicine
Recent genetic and genomic advancements have elucidated the complex etiology of
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …
idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases …
Senescence of alveolar epithelial progenitor cells: A critical driver of lung fibrosis
Pulmonary fibrosis comprises a range of chronic interstitial lung diseases (ILDs) that impose
a significant burden on patients and public health. Among these, idiopathic pulmonary …
a significant burden on patients and public health. Among these, idiopathic pulmonary …
Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress
Q Wu, C Liu, D Liu, Y Wang, H Qi, X Liu… - Science of The Total …, 2024 - Elsevier
It has been shown that exposure to nanoplastics (MNPs) through inhalation can induce
pulmonary toxicity, but the toxicological mechanism of MNPs on the respiratory system …
pulmonary toxicity, but the toxicological mechanism of MNPs on the respiratory system …
Chronic Expression of a Clinical SFTPC Mutation Causes Murine Lung Fibrosis with Idiopathic Pulmonary Fibrosis Features
L Rodriguez, Y Tomer, P Carson… - American Journal of …, 2023 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic interstitial lung disease. A
barrier to develo** more effective therapies for IPF is the dearth of preclinical models that …
barrier to develo** more effective therapies for IPF is the dearth of preclinical models that …
Inhibition of IRE1α/XBP1 axis alleviates LPS-induced acute lung injury by suppressing TXNIP/NLRP3 inflammasome activation and ERK/p65 signaling pathway
S Wang, L Hu, Y Fu, F Xu, Y Shen, H Liu, L Zhu - Respiratory Research, 2024 - Springer
Background Acute lung injury or acute respiratory distress syndrome (ALI/ARDS) is a
devastating clinical syndrome with high incidence and mortality rates. IRE1α-XBP1 pathway …
devastating clinical syndrome with high incidence and mortality rates. IRE1α-XBP1 pathway …
Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium
JP Bridges, EK Vladar, JS Kurche, A Krivoi… - The Journal of Clinical …, 2025 - jci.org
Idiopathic pulmonary fibrosis (IPF) is etiologically complex, with well-documented genetic
and nongenetic origins. In this Review, we speculate that the development of IPF requires …
and nongenetic origins. In this Review, we speculate that the development of IPF requires …
Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome
JY Wang, SN Michki, S Sitaraman, BJ Banaschewski… - JCI insight, 2024 - insight.jci.org
Hermansky-Pudlak syndrome (HPS) is a genetic disorder of endosomal protein trafficking
associated with pulmonary fibrosis in specific subtypes, including HPS-1 and HPS-2. Single …
associated with pulmonary fibrosis in specific subtypes, including HPS-1 and HPS-2. Single …
Consumption of Endogenous Caspase‐3 Activates Molecular Theranostic Nanoplatform against Inflammation‐Induced Profibrotic Positive Feedback in Pulmonary …
QL Li, X Chang, YM Han, ZC Guo, YN Liu… - Advanced …, 2025 - Wiley Online Library
The limited and backward diagnostic approaches elicit high mortality associated with
pulmonary fibrosis (PF) because they fail to identify injury phase of PF. Develo** a …
pulmonary fibrosis (PF) because they fail to identify injury phase of PF. Develo** a …
Activation of Alveolar Epithelial ER Stress by β-Coronavirus Infection Disrupt Surfactant Homeostasis in Mice: Implications for Covid-19 Respiratory Failure
COVID-19 syndrome is characterized by acute lung injury, hypoxemic respiratory failure,
and high mortality. Alveolar Type 2 (AT2) cells are essential for gas exchange, repair, and …
and high mortality. Alveolar Type 2 (AT2) cells are essential for gas exchange, repair, and …