Radiotherapy combined with immune checkpoint inhibitors in locally advanced/metastatic esophageal squamous cell carcinoma: clinical trials, efficacy and future …

M Jiang, Y Hu, G Lin, C Chen, H Li - Frontiers in Immunology, 2023 - frontiersin.org
Esophageal squamous cell carcinoma (ESCC) is a common malignancy worldwide and
often diagnosed at advanced stages with poor prognosis. Combination of radiotherapy and …

Trends in epidemiology of esophageal cancer in the US, 1975-2018

GM Rodriguez, D DePuy, M Aljehani, J Bien… - JAMA network …, 2023 - jamanetwork.com
Importance Esophageal cancer (EC) is the 7th most common cancer worldwide and 14th in
the US. More data are needed to study the changing incidence patterns of its 2 primary …

[HTML][HTML] A phase II clinical trial of toripalimab combined with neoadjuvant chemoradiotherapy in locally advanced esophageal squamous cell carcinoma …

R Chen, Q Liu, Q Li, Y Zhu, L Zhao, S Liu, B Chen… - …, 2023 - thelancet.com
Background To evaluate the efficacy and safety of toripalimab combined with neoadjuvant
chemoradiotherapy (NCRT) for locally advanced esophageal squamous cell carcinoma …

Lipid core-shell nanoparticles co-deliver FOLFOX regimen and siPD-L1 for synergistic targeted cancer treatment

W Cao, X Zhang, R Li, Z Li, A Lu, F Yu, L Sun… - Journal of Controlled …, 2024 - Elsevier
FOLFOX regimen, composed of folinic acid, 5-fluorouracil (5-FU) and oxaliplatin (OXP), has
been used as clinical standard therapeutic regimen in treatments of colorectal cancer (CRC) …

Advancements in immunotherapy for advanced esophageal squamous cell carcinoma: a comprehensive review of current strategies and future directions

Y Zhang, Z Li, Y Huang, Y Xu, B Zou - Expert Review of Clinical …, 2024 - Taylor & Francis
Introduction Esophageal cancer (EC), particularly esophageal squamous cell carcinoma
(ESCC), is characterized by high incidence and poor prognosis worldwide, necessitating …

[HTML][HTML] Analysis of multiple programmed cell death-related prognostic genes and functional validations of necroptosis-associated genes in oesophageal squamous …

K Cao, J Zhu, M Lu, J Zhang, Y Yang, X Ling… - …, 2024 - thelancet.com
Background Oesophageal squamous cell carcinoma (ESCC) is a lethal malignancy.
Immune checkpoint inhibitors (ICIs) showed great clinical benefits for patients with ESCC …

Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma

Z Yang, H Tian, X Chen, B Li, G Bai, Q Cai, J Xu… - Nature …, 2024 - nature.com
Neoadjuvant immunochemotherapy (nICT) has dramatically changed the treatment
landscape of operable esophageal squamous cell carcinoma (ESCC), but factors …

Impacts of tumor microenvironment during neoadjuvant chemotherapy in patients with esophageal squamous cell carcinoma

K Sugawara, T Fukuda, C Murakami, D Oka… - Cancer …, 2024 - Wiley Online Library
With the advent of immune checkpoint inhibitors (ICIs), a better understanding of tumor
microenvironment (TME) is becoming crucial in managing esophageal squamous cell …

Impact of metastatic lymph nodes on survival of patients with pn1-category esophageal squamous cell carcinoma: a long-term survival analysis

K Li, K Du, C Li, W He, S Lu, K Liu, C Wang… - Annals of Surgical …, 2024 - Springer
Background The morbidity and mortality rates of esophageal squamous cell carcinoma
(ESCC) are high in China. The overall survival (OS) of patients with ESCC is related to …

Premature mortality for patients after completely resected early adenocarcinoma of the esophagus or stomach

E Bollschweiler, AH Hölscher, SR Markar… - Cancer …, 2024 - Wiley Online Library
Objective To establish the life expectancy burden of esophago‐gastric cancer by analyzing
years of life lost (YLL) for a Western patient population after treatment of early esophageal …