Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …

Thrombospondin 1 (TSP1) is a matricellular extracellular matrix protein that has diverse
roles in regulating cellular processes important for the pathogenesis of fibrotic diseases. We …

Thymoquinone, a major ingredient of black seed oil (Nigella sativa), has been shown to
exhibit anticancer capacity in various types of cancers. However, there are few studies …

Thrombospondin-1 (TSP-1) is a matricellular extracellular matrix protein. Matricellular
proteins are components of the extracellular matrix (ECM) that regulate key cellular functions …

Endoplasmic reticulum (ER) stress is a key factor contributing to fibrotic disease. Although
ER stress is a short-term adaptive response, with chronic stimulation, it can activate …

Previously, our lab showed that the endoplasmic reticulum (ER) and calcium regulatory
protein, calreticulin (CRT), is important for collagen transcription, secretion, and assembly …

Although a disintegrin and metalloproteinase-17 (ADAM17) overexpression has been
demonstrated in numerous human tumors including gastric cancer, its role in gastric cancer …

Topical application of extracellular calreticulin (eCRT), an ER chaperone protein, in animal
models enhances wound healing and induces tissue regeneration evidenced by epidermal …

Objective—In resistance arteries, endothelial cell (EC) extensions can make contact with
smooth muscle cells, forming myoendothelial junction at holes in the internal elastic lamina …

Acute Kidney injury (AKI) is characterized by a sudden, and usually reversible, decline in
kidney function. In mice, ischemia reperfusion injury (IRI) is commonly used to model the …