Objective To consolidate evidence from systematic reviews and meta-analyses investigating
the association between reproductive factors in women of reproductive age and their …

Background Approximately 50% of cardiovascular disease (CVD) cases are attributable to
lifestyle risk factors. Despite widespread education, personal knowledge, and efficacy, many …

Risk for atherosclerotic cardiovascular disease (ASCVD) shows considerable heterogeneity
both in generally healthy persons and in those with known ASCVD. The foundation of …

Human aging is associated with an increased frequency of somatic mutations in
hematopoietic cells. Several of these recurrent mutations, including those in the gene …

Background: Absence of cardiovascular risk factors (CVRFs) is traditionally considered low
risk for atherosclerosis; however, individuals without CVRFs, as currently defined, still have …

Abstract Machine learning (ML) refers to computational algorithms that iteratively improve
their ability to recognize patterns in data. The digitization of our healthcare infrastructure is …

Background—Data are limited on the presence, distribution, and extent of subclinical
atherosclerosis in middle-aged populations. Methods and Results—The PESA (Progression …

Background Both the triglyceride-glucose (TyG) index, as a surrogate marker of insulin
resistance, and systemic inflammation are predictors of cardiovascular diseases; however …

Early disease detection is not only vital to reduce disease severity and prevent
complications, but also critical to increase success rate of therapy. Saliva has been studied …

Background In patients with established cardiovascular disease, residual cardiovascular risk
persists despite the achievement of target low-density lipoprotein (LDL) cholesterol levels …