Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

Matrigel, a mouse tumor extracellular matrix protein mixture, is an indispensable component
of most organoid tissue culture. However, it has limited the utility of organoids for drug …

Tissue and organ biology are very challenging to study in mammals, and progress can be
hindered, particularly in humans, by sample accessibility and ethical concerns. However …

Colorectal cancer (CRC) patient-derived organoids predict responses to chemotherapy.
Here we used them to investigate relapse after treatment. Patient-derived organoids expand …

The recent advances in in vitro 3D culture technologies, such as organoids, have opened
new avenues for the development of novel, more physiological human cancer models. Such …

In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Organoids have extensive therapeutic potential and are increasingly opening up new
avenues within regenerative medicine. However, their clinical application is greatly limited …

The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells
and have predictive value supporting personalized medicine. Here we describe a large …