Sepsis-associated acute kidney injury (SA-AKI) is common in critically ill patients and is
strongly associated with adverse outcomes, including an increased risk of chronic kidney …

Key Points Sepsis and Septic Shock Sepsis is a syndrome of life-threatening acute organ
dysfunction due to bacterial, fungal, parasitic, or viral infection. Factors that affect the risk of …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …

Background Whether the use of balanced multielectrolyte solution (BMES) in preference to
0.9% sodium chloride solution (saline) in critically ill patients reduces the risk of acute kidney …

Clinical and pathophysiological understanding of septic shock has progressed exponentially
in the previous decades, translating into a steady decrease in septic shock-related morbidity …

Background The comparative efficacy and safety of balanced crystalloid solutions and saline
for fluid therapy in critically ill adults remain uncertain. Methods We systematically reviewed …

Background Delayed graft function (DGF) is a major adverse complication of deceased
donor kidney transplantation. Intravenous fluids are routinely given to patients receiving a …

Background Severe trauma represents a major global public health burden and the
management of post-traumatic bleeding continues to challenge healthcare systems around …

Importance Approximately 20% to 30% of patients admitted to an intensive care unit have
sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids …

In December 2019, a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
was discovered in Wuhan, China, the rapid spread of which culminated in a global …