Pleiotropic effects of mitochondria in aging
Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …
Regulation of and challenges in targeting NAD+ metabolism
Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …
Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
NAD+ Metabolism in Cardiac Health, Aging, and Disease
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
[HTML][HTML] Molecular properties and regulation of NAD+ kinase (NADK)
S Oka, AS Titus, D Zablocki, J Sadoshima - Redox Biology, 2023 - Elsevier
Nicotinamide adenine dinucleotide (NAD+) kinase (NADK) phosphorylates NAD+, thereby
producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and …
producing nicotinamide adenine dinucleotide phosphate (NADP). Both NADK genes and …
Enhancing healthy aging with small molecules: A mitochondrial perspective
X Qin, H Li, H Zhao, L Fang… - Medicinal Research …, 2024 - Wiley Online Library
The pursuit of enhanced health during aging has prompted the exploration of various
strategies focused on reducing the decline associated with the aging process. A key area of …
strategies focused on reducing the decline associated with the aging process. A key area of …
[КНИГА][B] Outlive: The science and art of longevity
P Attia - 2023 - books.google.com
# 1 NEW YORK TIMES BESTSELLER• OVER TWO MILLION COPIES SOLD• A
groundbreaking manifesto on living better and longer that challenges the conventional …
groundbreaking manifesto on living better and longer that challenges the conventional …
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice
Mice bred in 2017 and entered into the C2017 cohort were tested for possible lifespan
benefits of (R/S)‐1, 3‐butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2‐activating …
benefits of (R/S)‐1, 3‐butanediol (BD), captopril (Capt), leucine (Leu), the Nrf2‐activating …
Aging is associated with increased brain iron through cortex-derived hepcidin expression
Iron is an essential molecule for biological processes, but its accumulation can lead to
oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is …
oxidative stress and cellular death. Due to its oxidative effects, iron accumulation is …
[HTML][HTML] Targeting organ-specific mitochondrial dysfunction to improve biological aging
CT Madreiter-Sokolowski, U Hiden, J Krstic… - Pharmacology & …, 2024 - Elsevier
In an aging society, unveiling new anti-aging strategies to prevent and combat aging-related
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …
diseases is of utmost importance. Mitochondria are the primary ATP production sites and key …