The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-
MS) techniques has provided substantial insights into the field of structural biology over the …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

Native ion mobility-mass spectrometry (IM-MS) is capable of revealing much that remains
unknown within the structural proteome, promising such information on refractory protein …

Proteins and the complexes they form with their ligands are the players of cellular action.
Their function is directly linked with their structure making the structural analysis of protein …

Ribonucleic acids (RNAs) remain challenging targets for structural biology, creating barriers
to understanding their vast functions in cellular biology and fully realizing their applications …

Native mass spectrometry coupled to ion mobility (IM-MS) has become an important tool for
the investigation of protein structure and dynamics upon ligand binding. Additionally …

Native ion mobility mass spectrometry (nIM-MS) has emerged as a useful technology for the
rapid evaluation of biomolecular structures. When combined with collisional activation in a …

Studies of large proteins, protein complexes, and membrane protein complexes pose new
challenges, most notably the need for increased ion mobility (IM) and mass spectrometry …

Ion mobility-mass spectrometry (IM-MS) and collision-induced unfolding (CIU) assays of
monoclonal antibody (mAb)-based biotherapeutics have proven sensitive to disulfide bridge …