Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

Despite the overwhelming success of vaccines in preventing infectious diseases, there
remain numerous globally devastating diseases without fully protective vaccines, particularly …

Dendritic cells (DC) are specialized immune cells that play a critical role in promoting an
immune response against Ags, which can include foreign pathogenic Ags and self-tumor …

Type 1 and advanced type 2 diabetes treatment involves daily injections or continuous
infusion of exogenous insulin aimed at regulating blood glucose levels in the …

Over the past several decades, much has been revealed about the nature of the host innate
immune response to microorganisms, with the identification of pattern recognition receptors …

Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies
(humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a …

Chimeric antigen receptors (CARs) have shown remarkable ability to re-direct T cells to
target CD19-expressing tumours, resulting in remission rates of up to 90% in individuals with …

Looking retrospectively at the development of humanity, vaccination is an unprecedented
medical landmark that saves lives by harnessing the human immune system. During the …

Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about
resistance to infection and silencing or tolerance to self. In the settings of infection and …