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Mycobacterium tuberculosis requires the outer membrane lipid phthiocerol dimycocerosate for starvation-induced antibiotic tolerance
AM Block, SB Namugenyi, NP Palani, AM Brokaw… - Msystems, 2023 - journals.asm.org
Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of
tuberculosis (TB) treatment and the emergence of drug-resistant strains. M. tuberculosis …
tuberculosis (TB) treatment and the emergence of drug-resistant strains. M. tuberculosis …
[HTML][HTML] Identification of covalent inhibitors that disrupt M. tuberculosis growth by targeting multiple serine hydrolases involved in lipid metabolism
The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a
global health threat necessitating the development of new antibiotics. Serine hydrolases …
global health threat necessitating the development of new antibiotics. Serine hydrolases …
Antibiotic resistance in Mycobacterium tuberculosis alters tolerance to cell wall-targeting inhibitors
Background A limited ability to eliminate drug-resistant strains of Mycobacterium
tuberculosis is a major contributor to the morbidity of TB. Complicating this problem, little is …
tuberculosis is a major contributor to the morbidity of TB. Complicating this problem, little is …
[HTML][HTML] Antimycobacterial activities of hydroxamic acids and their Iron (II/III), Nickel (II), copper (II) and zinc (II) complexes
D Yang, Y Zhang, IS Sow, H Liang, N El Manssouri… - Microorganisms, 2023 - mdpi.com
Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with
various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different …
various numbers of carbon atoms (C2, C6, C8, C10, C12 and C17), complexed with different …
Interplays between copper and Mycobacterium tuberculosis GroEL1
D Yang, DP Klebl, S Zeng, F Sobott, M Prévost… - Metallomics, 2020 - academic.oup.com
The recalcitrance of pathogenic Mycobacterium tuberculosis, the agent of tuberculosis, to
eradication is due to various factors allowing bacteria to escape from stress situations. The …
eradication is due to various factors allowing bacteria to escape from stress situations. The …
Selection of new therapeutic targets in relation to lipid metabolism in Mycobacterium abscessus
T Dargham - 2024 - hal.science
Lipid droplets are conserved organelles in a large number of organisms, playing an
essential role in energy storage and membrane renewal. Among prokaryotes …
essential role in energy storage and membrane renewal. Among prokaryotes …
A screen of covalent inhibitors in Mycobacterium tuberculosis identifies serine hydrolases involved in lipid metabolism as potential therapeutic targets
The increasing incidence of antibiotic-resistant Mycobacterium tuberculosis infections is a
global health threat necessitating the development of new antibiotics. Serine hydrolases …
global health threat necessitating the development of new antibiotics. Serine hydrolases …