Autophagy is a lysosome-dependent intracellular degradation system required for various
physiological processes and can be dysregulated in human disease. To understand its …

The genetics and pathophysiology of Parkinson's disease (PD) strongly implicate
mitochondria in disease aetiology. Elegant studies over the last two decades have …

Inflammatory damage contributes to β cell failure in type 1 and 2 diabetes (T1D and T2D,
respectively). Mitochondria are damaged by inflammatory signaling in β cells, resulting in …

Significance: Type 2 diabetes mellitus, which is related to oxidative stress and mitochondrial
dysfunction, is one of the most prevalent diseases in the world. In the past decade …

Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a
crucial role in maintaining metabolic balance and preventing insulin resistance, both key …

Insulin-producing pancreatic β-cells are central to glucose homeostasis, and their failure is a
principal driver of diabetes development. To preserve optimal health β-cells must withstand …

Pancreatic β cells are central to glycemic regulation through insulin production. Studies
show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic …

Impeded autophagy can impair pancreatic β cell function by causing apoptosis, of which
DAP-related apoptosis-inducing kinase-2 (DRAK2) is a critical regulator. Here, we identified …

Neurodegenerative diseases (NDDs), such as Parkinson's disease (PD) and Alzheimer's
disease (AD), are devastating brain diseases and are incurable at the moment. Increasing …

Mitochondrial dysfunction and aberrant mitochondrial homeostasis are key aspects of
Parkinson's disease (PD) pathophysiology. Mutations in PINK1 and Parkin proteins lead to …