Diabetes adversely affects multiple organs, including the kidney, eye and nerve, leading to
diabetic kidney disease, diabetic retinopathy and diabetic neuropathy, respectively. In both …

Dyslipidaemia is a hallmark of chronic kidney disease (CKD). The severity of dyslipidaemia
not only correlates with CKD stage but is also associated with CKD-associated …

Chronic inflammation is postulated to be involved in the development of end-stage renal
disease in diabetes, but which specific circulating inflammatory proteins contribute to this …

Background Urinary protein quantification is critical for assessing the severity of chronic
kidney disease (CKD). However, the current procedure for determining the severity of CKD …

Multi-tyrosine kinase inhibitors (MTKIs) have thus far had limited success in the treatment of
castration-resistant prostate cancer (CRPC). Here, we report a phase I–cleared orally …

Lipids are vital biological molecules and play multiple roles in cellular function of
mammalian organisms such as cellular membrane anchoring, signal transduction, material …

Chronic kidney diseases (CKDs) are currently classified according to their clinical features,
associated comorbidities and pattern of injury on biopsy. Even within a given classification …

Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

Studies of lipids in CKD, including ESRD, have been limited to measures of conventional
lipid profiles. We aimed to systematically identify 17 different lipid classes and associate the …

Dysregulation in lipid metabolism is the leading cause of chronic kidney disease (CKD) and
also the important risk factors for high morbidity and mortality. Although lipid abnormalities …