[HTML][HTML] Chemokine-directed tumor microenvironment modulation in cancer immunotherapy

P Bule, SI Aguiar, F Aires-Da-Silva… - International journal of …, 2021 - mdpi.com
Chemokines are a large family of small chemotactic cytokines that coordinates immune cell
trafficking. In cancer, they have a pivotal role in the migration pattern of immune cells into the …

Tumor metastasis: Mechanistic insights and therapeutic interventions

M Liu, J Yang, B Xu, X Zhang - MedComm, 2021 - Wiley Online Library
Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

CCR7 as a therapeutic target in Cancer

A Salem, M Alotaibi, R Mroueh, HA Basheer… - … et Biophysica Acta (BBA …, 2021 - Elsevier
The CCR7 chemokine axis is comprised of chemokine ligand 21 (CCL21) and chemokine
ligand 19 (CCL19) acting on chemokine receptor 7 (CCR7). This axis plays two important …

Chemokines and chemokine receptors: orchestrating tumor metastasization

E Marcuzzi, R Angioni, B Molon, B Calì - International journal of molecular …, 2018 - mdpi.com
Metastasis still represents the primary cause of cancer morbidity and mortality worldwide.
Chemokine signalling contributes to the overall process of cancer growth and metastasis …

CXCR4/CXCL12 axis:“old” pathway as “novel” target for anti‐inflammatory drug discovery

L Lu, J Li, X Jiang, R Bai - Medicinal Research Reviews, 2024 - Wiley Online Library
Inflammation is the body's defense response to exogenous or endogenous stimuli, involving
complex regulatory mechanisms. Discovering anti‐inflammatory drugs with both …

The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review

T Abdul-Rahman, S Ghosh, SM Badar, A Nazir… - European Journal of …, 2024 - Springer
Tumor progression and eradication have long piqued the scientific community's interest.
Recent discoveries about the role of chemokines and cytokines in these processes have …

Angiopoietin-like 4 protein elevates the prosurvival intracellular O2−: H2O2 ratio and confers anoikis resistance to tumors

P Zhu, MJ Tan, RL Huang, CK Tan, HC Chong, M Pal… - Cancer cell, 2011 - cell.com
Cancer is a leading cause of death worldwide. Tumor cells exploit various signaling
pathways to promote their growth and metastasis. To our knowledge, the role of angiopoietin …

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy

RL Sleightholm, BK Neilsen, J Li, MM Steele… - Pharmacology & …, 2017 - Elsevier
Chemokine networks regulate a variety of cellular, physiological, and immune processes.
These normal functions can become appropriated by cancer cells to facilitate a more …

CXCL12–CXCR4 signalling axis confers gemcitabine resistance to pancreatic cancer cells: a novel target for therapy

S Singh, SK Srivastava, A Bhardwaj, LB Owen… - British journal of …, 2010 - nature.com
Background: Pancreatic cancer cells are highly resistant to drug therapy; however,
underlying causes remain largely unknown. We hypothesised that the activation of CXCL12 …

Three-dimensional bioprinting of tissue-engineered skin: Biomaterials, fabrication techniques, challenging difficulties, and future directions: A review

Q Wei, Y An, X Zhao, M Li, J Zhang - International Journal of Biological …, 2024 - Elsevier
As an emerging new manufacturing technology, Three-dimensional (3D) bioprinting
provides the potential for the biomimetic construction of multifaceted and intricate …