Cell competition in development, homeostasis and cancer
Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …
that collectively regulate tissue architecture and function. To ensure the highest tissue …
Untangling the web of intratumour heterogeneity
Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and
disease progression. Technological and computational advances have enabled us to …
disease progression. Technological and computational advances have enabled us to …
Multiomic analysis of malignant pleural mesothelioma identifies molecular axes and specialized tumor profiles driving intertumor heterogeneity
Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and
challenging clinical management. Through a large series of whole-genome sequencing …
challenging clinical management. Through a large series of whole-genome sequencing …
Extracellular vesicles and particles impact the systemic landscape of cancer
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …
The evolutionary theory of cancer: challenges and potential solutions
The clonal evolution model of cancer was developed in the 1950s–1970s and became
central to cancer biology in the twenty-first century, largely through studies of cancer …
central to cancer biology in the twenty-first century, largely through studies of cancer …
Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites
Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …
Predictive validity in drug discovery: what it is, why it matters and how to improve it
JW Scannell, J Bosley, JA Hickman… - Nature Reviews Drug …, 2022 - nature.com
Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …
biological deserts. Screens in disease models, and other decision tools used in drug …
Inflammation: A new look at an old problem
E Gusev, Y Zhuravleva - International Journal of Molecular Sciences, 2022 - mdpi.com
Pro-inflammatory stress is inherent in any cells that are subject to damage or threat of
damage. It is defined by a number of universal components, including oxidative stress …
damage. It is defined by a number of universal components, including oxidative stress …
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
The evolution of established cancers is driven by selection of cells with enhanced fitness.
Subclonal mutations in numerous epigenetic regulator genes are common across cancer …
Subclonal mutations in numerous epigenetic regulator genes are common across cancer …
Deciphering tumour heterogeneity: from tissue to liquid biopsy
Simple Summary Most malignant tumours are highly heterogeneous at molecular and
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …
phenotypic levels. Tumour variability poses challenges for the management of patients, as it …