The physiology and pathophysiology of T-tubules in the heart
In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
important for triggering contraction by excitation-contraction (EC) coupling. These structures …
Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals
Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …
recent advances in cell-based models, including human-induced pluripotent stem cell …
Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids
The study of cardiac physiology is hindered by physiological differences between humans
and small-animal models. Here we report the generation of multi-chambered self-paced …
and small-animal models. Here we report the generation of multi-chambered self-paced …
A comparative review on heart ion channels, action potentials and electrocardiogram in rodents and human: extrapolation of experimental insights to clinic
S Joukar - Laboratory Animal Research, 2021 - Springer
Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for
investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart …
investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart …
Key characteristics of cardiovascular toxicants
L Lind, JA Araujo, A Barchowsky… - Environmental …, 2021 - ehp.niehs.nih.gov
Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards …
called key characteristics (KCs) was first developed to identify carcinogenic hazards …
Adapting to a new environment: postnatal maturation of the human cardiomyocyte
The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …
stimulated by the transition from the intrauterine to extrauterine environment. With birth …
Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology, as compared with bisphenol A
Bisphenol A (BPA) is a high-production volume chemical used to manufacture consumer
and medical-grade plastic products. Due to its ubiquity, the general population can incur …
and medical-grade plastic products. Due to its ubiquity, the general population can incur …
Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications
Animal experimentation is key in the evaluation of cardiac efficacy and safety of novel
therapeutic compounds. However, interspecies differences in the mechanisms regulating …
therapeutic compounds. However, interspecies differences in the mechanisms regulating …
Diffuse fibrosis and repolarization disorders explain ventricular arrhythmias in Brugada syndrome: a computational study
In this work, we reported a computational study to quantitatively determine the individual
contributions of three candidate arrhythmic factors associated with Brugada Syndrome. In …
contributions of three candidate arrhythmic factors associated with Brugada Syndrome. In …
[HTML][HTML] Promising tools for future drug discovery and development in antiarrhythmic therapy
G Mondéjar-Parreño, P Sánchez-Pérez, FM Cruz… - Pharmacological …, 2024 - Elsevier
Arrhythmia refers to irregularities in the rate and rhythm of the heart, with symptoms
spanning from mild palpitations to life-threatening arrhythmias and sudden cardiac death …
spanning from mild palpitations to life-threatening arrhythmias and sudden cardiac death …