The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Integrins are transmembrane receptors that have been implicated in the biology of various
human physiological and pathological processes. These molecules facilitate cell …

Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

The development of effective treatments for cancers requires investigations for a more
detailed and comprehensive understanding of the basic cellular mechanisms involved in …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Integrins are a family of heterodimeric receptors that bind to components of the extracellular
matrix and influence cellular processes as varied as proliferation and migration. These …

Directional migration is an important component of cell motility. Although the basic
mechanisms of random cell movement are well characterized, no single model explains the …