Understanding how individual neurons integrate the thousands of synaptic inputs they
receive is critical to understanding how the brain works. Modeling studies in silico and …

IBM's Blue Gene supercomputer allows a quantum leap in the level of detail at which the
brain can be modelled. I argue that the time is right to begin assimilating the wealth of data …

It is not known whether the variability of neural activity in the cerebral cortex carries
information or reflects noisy underlying mechanisms. In an examination of the reliability of …

Although signaling between neurons is central to the functioning of the brain, we still do not
understand how the code used in signaling depends on the properties of synaptic …

The temporal resolution of neuronal integration depends on the time window within which
excitatory inputs summate to reach the threshold for spike generation. Here, we show that in …

The role of back-propagating dendritic action potentials in the induction of long-term
potentiation (LTP) was investigated in CA1 neurons by means of dendritic patch recordings …

THE dendrites of neurons in the mammalian central nervous system have been considered
as electrically passive structures which funnel synaptic potentials to the soma and axon …

Recording of glutamate-activated currents in membrane patches was combined with RT-
PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of …

1. Dual voltage recordings were made from pairs of adjacent, synaptically connected thick
tufted layer 5 pyramidal neurones in brain slices of young rat (14‐16 days) somatosensory …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …