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Privileged Small Molecules against Neglected Tropical Diseases: A Perspective from Structure Activity Relationships
JA Shiran, B Kaboudin, N Panahi… - European Journal of …, 2024 - Elsevier
Neglected tropical diseases (NTDs) comprise a diverse set of infections with predominant
incidence in tropical and sub-tropical areas of the world. In spite of preventive and …
incidence in tropical and sub-tropical areas of the world. In spite of preventive and …
Modular and divergent synthesis of 2, N 3-disubstituted 4-quinazolinones facilitated by regioselective N-alkylation
KE Kim, JR Comber, AJ Pursel, GC Hobby… - Organic & …, 2024 - pubs.rsc.org
The synthesis of a biologically relevant 2-amino-N3-alkylamido 4-quinazolinone has been
accomplished in four steps from commercially available materials using design principles …
accomplished in four steps from commercially available materials using design principles …
Facile Amide Bond Formation with TCFH–NMI in an Organic Laboratory Course
OW M. Baldwin, LH Conrad-Marut… - Journal of chemical …, 2022 - ACS Publications
A new undergraduate organic laboratory experiment has been developed for amide bond
formation between biorenewable 2-furoic acid and either of two substituted piperazines to …
formation between biorenewable 2-furoic acid and either of two substituted piperazines to …
A Multidisciplinary Team-Based Classroom Exercise for Small Molecule Drug Discovery
Industrial drug discovery teams encompass scientists from multiple specialties and require
participants to communicate effectively across disciplinary boundaries. In this paper, we …
participants to communicate effectively across disciplinary boundaries. In this paper, we …
Synthesis of Vismodegib Derivatives as Potential Smo Agonist: A Case of Undergraduate Experimental Teaching
XF Bao, MY Zhong, ZX Wu, QY Zhang, LL Wang… - Russian Journal of …, 2023 - Springer
The activation of Hh pathway demonstrates therapeutic potential for many diseases. Smo is
the main target for the development of Hh pathway modulators. However, compared with …
the main target for the development of Hh pathway modulators. However, compared with …