Microneedle system for tissue engineering and regenerative medicine

Y Zhang, Y Xu, H Kong, J Zhang, HF Chan… - …, 2023 - Wiley Online Library
Global increasing demand for high life quality and length facilitates the development of
tissue engineering and regenerative medicine, which apply multidisciplinary theories and …

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

H Newman, YV Shih, S Varghese - Biomaterials, 2021 - Elsevier
Impaired bone healing occurs in 5–10% of cases following injury, leading to a significant
economic and clinical impact. While an inflammatory response upon injury is necessary to …

Injectable immunomodulation-based porous chitosan microspheres/HPCH hydrogel composites as a controlled drug delivery system for osteochondral regeneration

X Ji, H Shao, X Li, MW Ullah, G Luo, Z Xu, L Ma, X He… - Biomaterials, 2022 - Elsevier
The inappropriate regenerated fibrous cartilage and subchondral bone of the injured
chondral defect ultimately cause degeneration of the regenerated cartilage, which …

Niobium carbide MXene augmented medical implant elicits bacterial infection elimination and tissue regeneration

C Yang, Y Luo, H Lin, M Ge, J Shi, X Zhang - ACS nano, 2020 - ACS Publications
Incurable bacterial infections, impenetrable microbial biofilm, and irreversible antibiotic
resistance are among the most dangerous threats for humans. With few effective strategies …

[HTML][HTML] MXene-integrated microneedle patches with innate molecule encapsulation for wound healing

L Sun, L Fan, F Bian, G Chen, Y Wang, Y Zhao - Research, 2021 - spj.science.org
Wound healing is a complex physiological process that involves coordinated phases such
as inflammation and neovascularization. Attempts to promote the healing process tend to …

Smart microneedle patches for wound healing and management

F Hu, Q Gao, J Liu, W Chen, C Zheng, Q Bai… - Journal of Materials …, 2023 - pubs.rsc.org
The number of patients with non-healing wounds is generally increasing globally, placing a
huge social and economic burden on every country. The complexity of the wound-healing …

Materials-based nanotherapeutics for injured and diseased bone

CS Lee, RK Singh, HS Hwang, NH Lee… - Progress in Materials …, 2023 - Elsevier
Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma,
infection, and osteosarcoma resection face significant challenges for complete recovery. The …

A review of biomimetic scaffolds for bone regeneration: toward a cell‐free strategy

S Jiang, M Wang, J He - Bioengineering & Translational …, 2021 - Wiley Online Library
In clinical terms, bone grafting currently involves the application of autogenous, allogeneic,
or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as …

Meteorin-like/Metrnl, a novel secreted protein implicated in inflammation, immunology, and metabolism: A comprehensive review of preclinical and clinical studies

Z Li, Z Gao, T Sun, S Zhang, S Yang, M Zheng… - Frontiers in …, 2023 - frontiersin.org
Meteorin-like, also known as Metrnl, Meteorin-β, Subfatin, and Cometin, is a novel secreted
protein exerting pleiotropic effects on inflammation, immunology, and metabolism. Earlier …

Multifunctional scaffolds for bone repair following age-related biological decline: Promising prospects for smart biomaterial-driven technologies

JD Schwartzman, M McCall, Y Ghattas… - Biomaterials, 2024 - Elsevier
The repair of large bone defects due to trauma, disease, and infection can be exceptionally
challenging in the elderly. Despite best clinical practice, bone regeneration within …