Early growth response factor 1 (EGR1) is a transcription factor that is mainly involved in the
processes of tissue injury, immune responses, and fibrosis. Recent studies have shown that …

Mammalian target of rapamycin (mTOR) is a kinase that functions as a master switch
between catabolic and anabolic metabolism and as such is a target for the design of …

Recent studies are reviewed indicating that the transcription factor early growth response-1
(Egr1) is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53, and …

The transcription factor EGR1 is a tumor suppressor gene that is downregulated in many
cancer types. Clinically, loss of EGR1 translates to increased tumor transformation and …

The functions ascribed to PTEN have become more diverse since its discovery as a putative
phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and …

Recently, the non-protein-coding functional elements in the human genome have been
identified as key regulators in postgenomic biology, and a large number of pseudogenes as …

Loss of a whole chromosome 5 or a deletion of the long arm, del (5q), is a recurring
abnormality in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML). To …

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …

Since the discovery by this laboratory of the zinc finger transcription factor, KLF10, a member
of the Krüppel-like family of transcription factors, there have been multiple publications …

Background The purpose of this study was to evaluate the role of differentiation-related
genes (DRGs) in tumor-associated macrophages (TAMs) in non-small cell lung cancer …