Frailty index as a biomarker of lifespan and healthspan: focus on pharmacological interventions
Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …
evolving towards incorporating healthspan and health indices in studies that explore aging …
Management of porcelain gallbladder, its risk factors, and complications: a review
The porcelain gallbladder condition describes gallbladder calcification. While gallbladder
calcification is believed to increase the risk of develo** gallbladder cancer, recent reports …
calcification is believed to increase the risk of develo** gallbladder cancer, recent reports …
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution
Breast cancer is the fifth leading cause of death, worldwide affecting both genders.
Accumulating evidence suggests that metformin, an oral hypoglycemic agent used in the …
Accumulating evidence suggests that metformin, an oral hypoglycemic agent used in the …
Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA
Objective This study aimed to evaluate the effectiveness of metformin versus placebo in
overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of …
overweight patients with knee osteoarthritis (OA). In addition, to assess the effects of …
[HTML][HTML] The effect of Tauroursodeoxycholic acid (TUDCA) and gut microbiota on murine gallbladder stone formation
Q Lu, Z Jiang, Q Wang, H Hu, G Zhao - Annals of Hepatology, 2021 - Elsevier
Abstract Introduction and Objectives The incidence of gallstone-related disease steadily
increased in the last few years. Here, we aimed to investigate the effect of …
increased in the last few years. Here, we aimed to investigate the effect of …
Targeted bile acid profiles reveal the liver injury amelioration of Da-Chai-Hu decoction against ANIT-and BDL-induced cholestasis
YH Zhou, YZ Zhou, YF Li, W Sun, ZL Wang… - Frontiers in …, 2022 - frontiersin.org
Multiple types of liver diseases, particularly cholestatic liver diseases (CSLDs) and biliary
diseases, can disturb bile acid (BA) secretion; however, BA accumulation is currently seen …
diseases, can disturb bile acid (BA) secretion; however, BA accumulation is currently seen …
[HTML][HTML] The role of MicroRNA networks in tissue-specific direct and indirect effects of metformin and its application
Q Yang, G Wang, D Fang, X Gao, Y Liang… - Biomedicine & …, 2022 - Elsevier
Metformin is a first-line oral antidiabetic agent that results in clear benefits in relation to
glucose metabolism and diabetes-related complications. The specific regulatory details and …
glucose metabolism and diabetes-related complications. The specific regulatory details and …
[HTML][HTML] Porcelain gallbladder
MW Jones, CB Weir, T Ferguson - 2018 - europepmc.org
Objectives: Review the etiology of porcelain gallbladder. Describe the pathophysiology of
porcelain gallbladder. Summarize the treatment options for porcelain gallbladder. Review …
porcelain gallbladder. Summarize the treatment options for porcelain gallbladder. Review …
GDF-15 as a therapeutic target of diabetic complications increases the risk of gallstone disease: Mendelian randomization and polygenic risk score analysis
L Yu, Y Zhou, L Wang, X Zhou, J Sun, J **ao… - Frontiers in …, 2022 - frontiersin.org
Growth differentiation factor 15 (GDF-15) levels have been revealed as a robust biomarker
for metformin use. We conducted Mendelian randomization (MR) analysis to explore the …
for metformin use. We conducted Mendelian randomization (MR) analysis to explore the …
Hypoglycemic drugs, circulating inflammatory proteins, and gallbladder diseases: A mediation mendelian randomization study
ZQ Wang, JY Zhang, X Tang, JB Zhou - Diabetes Research and Clinical …, 2024 - Elsevier
Background The relationship of hypoglycemic drugs, inflammatory proteins and gallbladder
diseases remain unknown. Methods Four hypoglycemic drugs were selected as exposure …
diseases remain unknown. Methods Four hypoglycemic drugs were selected as exposure …