Biological and pharmacological activities of Amaryllidaceae alkaloids

M He, C Qu, O Gao, X Hu, X Hong - Rsc advances, 2015 - pubs.rsc.org
The amaryllidaceae family consists of about 75 genera and 1100 species that are wide-
spread in the tropics and warm temperate regions of the world. Since the first isolation of …

Phytochemical and biological investigations of Amaryllidaceae alkaloids: a review

Y Ding, D Qu, KM Zhang, XX Cang… - Journal of Asian …, 2017 - Taylor & Francis
Amaryllidaceae is a family that includes 75 genera and about 1100 species, which have a
long history of medicinal use. Many plants have been proven to possess efficacy for …

Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an …

D Lamoral-Theys, A Andolfi… - Journal of medicinal …, 2009 - ACS Publications
Twenty-two lycorine-related compounds were investigated for in vitro antitumor activity using
four cancer cell lines displaying different levels of resistance to proapoptotic stimuli and two …

Anticancer and reversing multidrug resistance activities of natural isoquinoline alkaloids and their structure-activity relationship

ZX Qing, JL Huang, XY Yang, JH Liu… - Current medicinal …, 2018 - ingentaconnect.com
The severe anticancer situation as well as the emergence of multidrug-resistant (MDR)
cancer cells has created an urgent need for the development of novel anticancer drugs with …

Application of the aza-Diels–Alder reaction in the synthesis of natural products

MH Cao, NJ Green, SZ Xu - Organic & Biomolecular Chemistry, 2017 - pubs.rsc.org
The Diels–Alder reaction that involves a nitrogen atom in the diene or dienophile is termed
the aza-Diels–Alder reaction. As well as the powerful all-carbon Diels–Alder reaction, the …

Towards a molecular understanding of the biosynthesis of Amaryllidaceae alkaloids in support of their expanding medical use

AM Takos, F Rook - International journal of molecular sciences, 2013 - mdpi.com
The alkaloids characteristically produced by the subfamily Amaryllidoideae of the
Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus …

Making natural products from renewable feedstocks: back to the roots?

J Kühlborn, J Groß, T Opatz - Natural Product Reports, 2020 - pubs.rsc.org
Covering: up to mid-2019 This review highlights the utilization of biomass-derived building
blocks in the total synthesis of natural products. An overview over several renewable …

Amaryllidaceae alkaloids: Absolute configuration and biological activity

A Cimmino, M Masi, M Evidente, S Superchi… - Chirality, 2017 - Wiley Online Library
Plants belonging to the Amaryllidaceae family are well known for their ornamental and
medicinal use. Plant members of this group are distributed through both tropical and …

Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells

G Van Goietsenoven, A Andolfi… - Journal of natural …, 2010 - ACS Publications
Fifteen Amaryllidaceae alkaloids (1− 15) were evaluated for their antiproliferative activities
against six distinct cancer cell lines. Several of these natural products were found to have …

Narciclasine–an Amaryllidaceae alkaloid with potent antitumor and anti-inflammatory properties

R Fürst - Planta medica, 2016 - thieme-connect.com
The isocarbostyril alkaloid narciclasine, also known as lycoricidinol, was discovered in
Narcissus species (Amaryllidaceae) in 1967. A few years later, the 60S subunit of …