Extensive angiogenesis is a characteristic feature in the synovial tissue of rheumatoid
arthritis (RA) from a very early stage of the disease onward and constitutes a crucial event …

The discovery and development of new 99mTc-based radiopharmaceuticals or labeled
drugs in general is based on innovative, pure chemistry and subsequent, application …

Rhenium-based metallodrugs have recently been highlighted as promising candidates for
new antibiotics to combat multi-drug resistant (MDR) pathogens. A new class of rhenium (V) …

Rheumatoid arthritis (RA) is a systemic autoimmune disorder caused by inflammation of
cartilaginous diarthrodial joints that destroys joints and cartilage, resulting in synovitis and …

The ability to append targeting biomolecules to chelators that efficiently coordinate to the
diagnostic imaging radionuclide, 99mTc, and the therapeutic radionuclide, 188Re, can …

We have developed a diphosphine (DP) platform for radiolabeling peptides with 99mTc and
64Cu for molecular SPECT and PET imaging, respectively. Two diphosphines, 2, 3-bis …

Bis (thiosemicarbazone) and pyridylhydrazone-thiosemicarbazone chelators have
demonstrated utility in nuclear medicine. In particular, the 64Cu2+ complexes have been …

Benchtop 99 Mo/99m Tc and 188 W/188 Re generators enable economical production of
molecular theranostic 99m Tc and 188 Re radiopharmaceuticals, provided that simple, kit …

Metallic radionuclides, radiometals, have an important role in nuclear medicine. Their
straightforward coordination radiochemistry allows for a large variety of applications. The …

This thesis examines a novel chemical platform for the development of new compounds for
use in medical nuclear imaging. Identification of the chemical properties and biological …