The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

Here we describe the LifeTime Initiative, which aims to track, understand and target human
cells during the onset and progression of complex diseases, and to analyse their response …

Background & Aims A large unmet therapeutic need exists in inflammatory bowel disease
(IBD). Inhibition of interleukin (IL)-6 appears to be effective, but the therapeutic benefit of a …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

Big data methodologies, made possible with the increasing generation and availability of
digital data and enhanced analytical capabilities, have produced new insights to improve …

Background Chronic inflammatory diseases in childhood and early adult life share
aetiological factors operating from birth and onwards. In this study, we use data from the …

Autoimmune liver diseases (AiLDs) are rare autoimmune conditions of the liver and the
biliary tree with unknown etiology and limited treatment options. AiLDs are inherently …

Demonstrating in an unambiguous manner that a diet, let alone a single product,'optimizes'
health, presents an enormous challenge. The least complicated is when the starting …

Background: Human and animal studies support the involvement of diet in the development
of CID-chronic inflammatory diseases such as inflammatory bowel disease, psoriasis …

Psoriasis is a chronic skin disease with underlying genetic, inflammatory and immunological
background, which is a great medical problem, currently regarded as a systemic condition …