Acute leukemia continues to be a major cause of death from disease worldwide and current
chemotherapeutic agents are associated with significant morbidity in survivors. While better …

Star polymers are structures composed of multiple functional linear arms covalently
connected through a central core. The unique conformation of star polymers, with their …

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There has been an explosion of knowledge about the role of metabolism and the
mitochondria in acute myeloid leukemia (AML). We have also recently seen several waves …

Background Despite advancements in chronic myeloid leukemia (CML) therapy with
tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges …

Sarcomas are driven by diverse pathogenic mechanisms, including gene rearrangements in
a subset of cases. Rare soft tissue sarcomas containing KMT2A fusions have recently been …

Around 10% of acute leukemias harbor a rearrangement of the MLL/KMT2A gene, and the
presence of this translocation results in a highly aggressive, therapy‐resistant leukemia …

Background The prognosis for high-risk childhood acute leukaemias remains dismal and
established treatment protocols often cause long-term side effects in survivors. This study …

The prognosis for children diagnosed with high-risk acute lymphoblastic leukemia (ALL)
remains suboptimal, and more potent and less toxic treatments are urgently needed. We …

MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in
cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or …