Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Preserving genome function and stability are paramount for ensuring cellular homeostasis,
an imbalance in which can promote diseases including cancer. In the presence of DNA …

DNA damage signaling is critical for the maintenance of genome integrity and cell fate
decision. Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA
damage signaling and repair within chromatin. In this study, we report the identification of …

The response to hypoxia is primarily mediated by the hypoxia-inducible transcription factor
(HIF). Levels of HIF are regulated by the oxygen-sensing HIF hydroxylases, members of the …

In 1963, Chambon et al. reported the detection of a nicotinamide mononucleotide-activated,
DNA-dependent enzymatic activity in rat liver extracts that catalyzed the synthesis of a …

Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …

Modulation of chromatin templates in response to cellular cues, including DNA damage,
relies heavily on the post-translation modification of histones. Numerous types of histone …

Epigenetic events include reversible modifications of DNA and histone tails driving
chromatin organization and thus transcription. The epigenetic regulation is a highly …