During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of
inadequate drug dissolution rates, is one of the most significant challenges that …

Silk fibroin (SF) is a protein-based biomacromolecule with excellent biocompatibility,
biodegradability and low immunogenicity. The development of SF-based nanoparticles for …

Solid lipid particulate systems such as solid lipid nanoparticles (SLN), lipid microparticles
(LM) and lipospheres have been sought as alternative carriers for therapeutic peptides …

Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4
MPa and 31.1° C. Given the request for consumption of a green solvent for the environment …

Catechins are a group of polyphenolic compounds that extensively occur in the plants. They
are widely used as nutraceutical for enhancing human health, pharmaceutical formulations …

The formulation of natural substances together with a biocompatible or biodegradable
carrier material to form composites or encapsulates has a great relevance for …

Micro-and nano-carrier formulations have been developed as drug delivery systems for
active pharmaceutical ingredients (APIs) that suffer from poor physico-chemical …

The solubility and bioavailability of pharmaceutical compounds are increased via size
reduction. The conventional size reduction methods have some disadvantages. The …

Recent developments in biodegradable particle formation using supercritical fluids and
dense gases have been reviewed with an emphasis on studies of micronizing and …