Network pharmacology: curing causal mechanisms instead of treating symptoms
For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …
discovery is in constant decline. While low quality, reproducibility issues, and translational …
Deep learning for drug repurposing: Methods, databases, and applications
Drug development is time‐consuming and expensive. Repurposing existing drugs for new
therapies is an attractive solution that accelerates drug development at reduced …
therapies is an attractive solution that accelerates drug development at reduced …
TTD: Therapeutic Target Database describing target druggability information
Y Zhou, Y Zhang, D Zhao, X Yu, X Shen… - Nucleic acids …, 2024 - academic.oup.com
Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for develo** first-in-class drug. A variety …
identification of promising targets is fundamental for develo** first-in-class drug. A variety …
[HTML][HTML] Cord-19: The covid-19 open research dataset
Abstract The C ovid-19 Open Research Dataset (CORD-19) is a growing 1 resource of
scientific papers on C ovid-19 and related historical coronavirus research. CORD-19 is …
scientific papers on C ovid-19 and related historical coronavirus research. CORD-19 is …
Network medicine framework for identifying drug-repurposing opportunities for COVID-19
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
SARS-CoV-2 antiviral therapy
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …
vaccination, as well as for those who do not respond robustly to vaccination. This review …
A review on drug repurposing applicable to COVID-19
Drug repurposing involves the identification of new applications for existing drugs at a lower
cost and in a shorter time. There are different computational drug-repurposing strategies and …
cost and in a shorter time. There are different computational drug-repurposing strategies and …
Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
devastated the global economy and claimed more than 1.7 million lives, presenting an …
devastated the global economy and claimed more than 1.7 million lives, presenting an …
Text mining approaches for dealing with the rapidly expanding literature on COVID-19
More than 50 000 papers have been published about COVID-19 since the beginning of
2020 and several hundred new papers continue to be published every day. This incredible …
2020 and several hundred new papers continue to be published every day. This incredible …
Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies
Responding quickly to unknown pathogens is crucial to stop uncontrolled spread of
diseases that lead to epidemics, such as the novel coronavirus, and to keep protective …
diseases that lead to epidemics, such as the novel coronavirus, and to keep protective …