Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …

The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Efficient control of energy metabolic homeostasis, enhanced stress resistance, and qualified
cellular housekee** are the hallmarks of improved healthspan and extended lifespan …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Protein kinase A (PKA) is a central regulator of cardiac performance and morphology.
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …

Aging leads to and is associated with aberrant function of multiple signaling pathways and a
host of factors that maintain cellular health. Under normal conditions, the prolongevity …

One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …